Mabel and the other Cartman relatives appeared prominently shortly after in the episode "Merry Christmas Charlie Manson!", in which her daughter Liane Cartman, along with Eric, Stan Marsh, Kyle Broflovski and Kenny McCormick go to spend Christmas with the Cartman family in Nebraska.
Cartman was particularly excited due to the fact that his grandmother always gave him spectacular gifts. However, he was sorely disappointed when Mable gave him a simple shirt, stating that she had gone senile and needed to be put into a home. The family would later enjoy a family dinner, along with Mable's son Howard Cartman, who was in prison and who joined the family via TV. Howard, along with his cell mate Charlie Manson would later break-out and hold the family hostage, until they were at last re-arrested by the police.
Grandma Mabel later died of an unknown cause, and the funeral was depicted in "Cartmanland". Cartman was furious at the funeral being held on a Saturday and complained throughout it all, stating "It didn't take her this long to die..." However at the reading of the will it was revealed that, she left her family next to nothing money-wise due to the fact that they would "Just spend it on crack". All of her wealth, which rounded off to a million dollars, was left to Eric, who used the money to buy his own amusement park.
Mabel appears to be quite old, with an aged face with many wrinkles. She wears a lavender colored sweater and gold-rimmed glasses. She has grey hair.
Like the rest of the Cartman family, she appears to have adopted some of Eric's mannerisms, albeit to a much lesser extent than most of her family members. She is generally much more level-headed and considerate than most of her family.
- "Roger Ebert Should Lay Off the Fatty Foods" - Speaks to Eric on the phone about the Cheesy Poofs commercial.
- "Merry Christmas Charlie Manson!" - She appears, along with the rest of the Cartman family, when the boys come to visit them in Nebraska.
- "Cartmanland" - She does not appear, but is mentioned posthumously. Eric attends her funeral and is overjoyed to learn that he is to inherit one million dollars from his grandmother.
- Cartman, trying to get back his $16.12 in "Scott Tenorman Must Die", tells Scott that his Grandma is dying, a few weeks later she actually does die in the episode "Cartmanland".
|style="background: #Template:Color1; color:#FFF; text-shadow:#000 .1em .1em .1em; padding-left:20px; border-radius:5px 5px 0px 0px;" align="center" colspan="2"|South Park families|
Broflovski Family | Cartman Family | Marsh Family | McCormick Family | Stotch Family | Biggle Family | Black Family | Cotswolds Family | Donovan Family | Gueermo Family | Hakeem Family | Harrison Family | Mephesto Family | Stevens Family | Tenorman Family | Testaburger Family | Tucker Family | Tweak Family | Valmer Family |